A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis. Subsequent uptake into target organs like skeletal muscle,...

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Principais autores:	Malte Stockebrand, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2018-06-01
Series:	Frontiers in Physiology
Assuntos:	creatine transporter skeletal muscle energy metabolism in vivo magnetic spectroscopy L-arginine:glycine amidinotransferase (AGAT) guanidinoacetate N-methyltransferase (GAMT)
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fphys.2018.00773/full
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