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Marginal zone B cells mediate humoral immunity in vaccine-induced versus naturally acquired immunity against SARS-CoV-2

Abstract The role of marginal zone B (MZB) cells in SARS-CoV-2 immunity remains unclear, particularly in comparing vaccine-induced responses to natural infection. MZB cells are crucial for rapid antibody responses, but their contributions to vaccine-induced immunity, especially in the elderly, are n...

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Principais autores: Jie Shu, Jiameng Yao, Meiyu Tan, Hanxiao Sun, Xiaohui Wu, Fengjun Chen, Binbin Xuan, Chenfei Du, Yunqi Pan, Lida Zhou, Hong Li, Yajie Wang, Chenxin Gan, Shengce Tao, Jinpiao Lin, Huiming Sheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-02-01
Serier:Scientific Reports
Fag:
Marginal zone B cells
SARS-CoV-2
Inactivated wholevirus
Vaccine
B cell receptor repertoire
Online adgang:https://doi.org/10.1038/s41598-026-38298-w
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