Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives

Abstract Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and the loss...

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Principais autores:	Chenliang Zhang, Tingting Huang, Liping Li
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2024-08-01
סדרה:	Journal of Hematology & Oncology
נושאים:	Copper Cuproptosis Cancer Tumor therapy Drug resistance Tumor immunotherapy
גישה מקוונת:	https://doi.org/10.1186/s13045-024-01589-8
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