TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.

<h4>Background</h4>TBX5 is a transcription factor that has an important role in development of heart. TBX5 variants in the region encoding the T-box domain have been shown to cause cardiac defects, such as atrial septal defect or ventricular septal defect, while TBX5 variants have also been identifi...

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Principais autores:	Nariaki Miyao, Yukiko Hata, Hironori Izumi, Ryo Nagaoka, Yuko Oku, Ichiro Takasaki, Taisuke Ishikawa, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Tomoyuki Yoshida, Hideyuki Hasegawa, Naomasa Makita, Naoki Nishida, Hisashi Mori, Fukiko Ichida, Keiichi Hirono
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2020-01-01
Series:	PLoS ONE
Acceso en liña:	https://doi.org/10.1371/journal.pone.0227393
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