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Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice

Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood....

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Principais autores: Eveline Gart, Wim van Duyvenvoorde, Jessica M. Snabel, Christa de Ruiter, Joline Attema, Martien P.M. Caspers, Serene Lek, Bertie Joan van Heuven, Arjen G.C.L. Speksnijder, Martin Giera, Aswin Menke, Kanita Salic, Kendra K. Bence, Gregory J. Tesz, Jaap Keijer, Robert Kleemann, Martine C. Morrison
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-03-01
Serier:Heliyon
Fag:
Non-alcoholic fatty liver disease
Temporal dynamics
Inter-organ crosstalk
Oxidative stress
Liver fibrosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844023011921
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