Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

IntroductionObesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking.MethodsIn this study we performed the histological and hi...

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Hlavní autoři:	Florine Seidel, Kees Fluiter, Robert Kleemann, Nicole Worms, Anita van Nieuwkoop, Martien P. M. Caspers, Nikolaos Grigoriadis, Amanda J. Kiliaan, Frank Baas, Iliana Michailidou, Martine C. Morrison
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-06-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	obesity aging brain neurodegeneration astrogliosis neuroinflammation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1205261/full
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