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Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants

Phosphatidylinositol 3-kinase, catalytic subunit alpha (PIK3CA) is an oncogene often mutated in colorectal cancer (CRC). The contribution of PIK3CA mutations in acquired resistance to anti-epidermal growth factor receptor (EGFR) therapy is well documented, but their prognostic and predictive value r...

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Bibliografische gegevens
Hoofdauteurs: Arman Ali Ghodsinia, J-Ann Marie T. Lego, Reynaldo L. Garcia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2020-04-01
Reeks:Cells
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Online toegang:https://www.mdpi.com/2073-4409/9/5/1116
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