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Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Erica Lynn Bradshaw-Pierce, Todd M Pitts, Aik-Choon eTan, Kelly eMcPhillips, Mark eWest, Daniel L Gustafson, Charles eHalsey, Leslie eNguyen, Nathan V Lee, Julie LC Kan, Brion William Murray, S. Gail eEckhardt
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2013-03-01
Rangatū:Frontiers in Pharmacology
Ngā marau:
P-Glycoprotein
colorectal cancer
PF-3758309
intrinsic resistance
mouse xenografts
Urunga tuihono:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00022/full
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