In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors

A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines <b>2</b>–<b>5</b> were designed, based on the structure of our previous lead compound <b>1</b> through the in silico structure-guided optimization approach. The results showed that some of these new compounds showed a good herbicidal...

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Principais autores:	Lijun Yang, Dawei Wang, Dejun Ma, Di Zhang, Nuo Zhou, Jing Wang, Han Xu, Zhen Xi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-11-01
Serija:	Molecules
Teme:	herbicidal activity molecular design phytoene desaturase pyridazine
Online dostop:	https://www.mdpi.com/1420-3049/26/22/6979
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