Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism

Abstract Background Pulmonary arterial hypertension (PAH) is a chronic, progressive lung vascular disease accompanied by elevated pulmonary vascular pressure and resistance, and it is characterized by increased pulmonary artery smooth muscle cell (PASMC) proliferation. Apolipoprotein A5 (ApoA5) impr...

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Hauptverfasser:	Jingyuan Chen, Jun Luo, Haihua Qiu, Yi Tang, Xiaojie Yang, Yusi Chen, Zilu Li, Jiang Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-08-01
Schriftenreihe:	Lipids in Health and Disease
Schlagworte:	Pulmonary arterial hypertension Apolipoprotein A5 Endoplasmic reticulum stress Glucose- regulated protein 78
Online-Zugang:	https://doi.org/10.1186/s12944-022-01680-4
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