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Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells

Abstract Background Depletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11). Therefore, RPL5 and RPL11 may link RPs and p53 activation. Thus, this study aimed to explore whether RPs interact with RPL...

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Main Authors: Hongyan Li, Hong Zhang, Guomin Huang, Zhitong Bing, Duling Xu, Jiadi Liu, Hongtao Luo, Xiaoli An
Format: Artigo
Language:Inglês
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ribosomal protein S27a (RPS27a)
Lung adenocarcinoma
Apoptosis
Online Access:https://doi.org/10.1186/s13046-021-02230-z
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