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Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms

BackgroundAbdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate the pathogenesis of AAA formation. Our hypoth...

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Gardado en:
Principais autores: Zachary Ladd, Gang Su, Joseph Hartman, Guanyi Lu, Sara Hensley, Gilbert R. Upchurch, Ashish K. Sharma
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cardiovascular Medicine
Assuntos:
abdominal aortic aneurysms
endothelial cells
spironolactone
pannexin 1
macrophages
smooth muscle cells (SMCs)
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1101389/full
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