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Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms

BackgroundAbdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate the pathogenesis of AAA formation. Our hypoth...

Celý popis

Uloženo v:
Hlavní autoři: Zachary Ladd, Gang Su, Joseph Hartman, Guanyi Lu, Sara Hensley, Gilbert R. Upchurch, Ashish K. Sharma
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2023-01-01
Edice:Frontiers in Cardiovascular Medicine
Témata:
abdominal aortic aneurysms
endothelial cells
spironolactone
pannexin 1
macrophages
smooth muscle cells (SMCs)
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1101389/full
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