Simultaneous imaging of redox states in dystrophic neurites and microglia at Aβ plaques indicate lysosome accumulation not microglia correlate with increased oxidative stress

The inter-relationship between microglia dynamics and oxidative stress (Ox-stress) in dystrophic neurites (DNs) at Alzheimer’s Disease (AD) plaques may contribute to the pathological changes in neurons. We developed new in vivo imaging strategies to combine EGFP expression in microglia with neuronal...

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Detalhes bibliográficos

Principais autores:	Stefan Wendt, Sora Johnson, Nicholas L. Weilinger, Christopher Groten, Stefano Sorrentino, Jonathan Frew, Lucy Yang, Hyun B. Choi, Haakon B. Nygaard, Brian A. MacVicar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-10-01
coleção:	Redox Biology
Assuntos:	Microglia Alzheimer’s disease Oxidative stress Neurodegeneration
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231722002208
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