A carrier-free self-assembling nanovaccine comprising a STING agonist and antigenic peptides for controlled immune activation

The stimulator of interferon genes (STING) pathway plays a central role in antitumor immunity. However, the clinical application of cyclic dinucleotides (CDNs) as STING agonists is hampered by their poor stability and hydrophilicity. Critically, the systemic administration of free CDNs can lead to t...

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Detalhes bibliográficos

Principais autores:	Tian-Yang Wang, Hong-Guo Hu, Geng-Hui Feng, Jing-Yun Su, Shao-Hua Zhuo, Zhuo Huang, Yan-Mei Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Tsinghua University Press 2026-04-01
Colecção:	Nano Research
Assuntos:	sting pathway nanovaccine self-assembling peptides antigen presentation lymph node cancer immunotherapy
Acesso em linha:	https://www.sciopen.com/article/10.26599/NR.2025.94908278
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