The role of impaired bone marrow Tregs in hematopoietic stem cell depletion for pediatric aplastic anemia probably involves immune privilege

Abstract Purpose An immune-mediated pathogenesis has been postulated for aplastic anemia (AA), and impaired Tregs and other immune abnormalities have been identified in patients with AA. However, the process by which abnormal immunity specifically damages hematopoietic stem cells (HSCs) remains uncl...

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Detalhes bibliográficos

Principais autores:	Can Huang, Shanshan Li, Jingwei Yang, Yangyang Jiao, Ting Zhang, Hui Jiang, Fanyi Zeng, Shayi Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-05-01
coleção:	Blood Research
Assuntos:	Aplastic anemia Immune privilege Hematopoietic stem cells Immune microenvironment Regulatory T cells
Acesso em linha:	https://doi.org/10.1007/s44313-026-00141-6
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