The role of impaired bone marrow Tregs in hematopoietic stem cell depletion for pediatric aplastic anemia probably involves immune privilege

Abstract Purpose An immune-mediated pathogenesis has been postulated for aplastic anemia (AA), and impaired Tregs and other immune abnormalities have been identified in patients with AA. However, the process by which abnormal immunity specifically damages hematopoietic stem cells (HSCs) remains uncl...

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Auteurs principaux:	Can Huang, Shanshan Li, Jingwei Yang, Yangyang Jiao, Ting Zhang, Hui Jiang, Fanyi Zeng, Shayi Jiang
Format:	Artigo
Langue:	Inglês
Publié:	Springer Nature 2026-05-01
Collection:	Blood Research
Sujets:	Aplastic anemia Immune privilege Hematopoietic stem cells Immune microenvironment Regulatory T cells
Accès en ligne:	https://doi.org/10.1007/s44313-026-00141-6
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