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CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors. C-reactive protein (CRP) in its activated, monomer...

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Principais autores: Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-08-01
Serier:Frontiers in Immunology
Fag:
innate immunity
host defense
C-reactive protein
reactive oxygen species
complement system
complement inhibition
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.721887/full
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