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The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine — the supraspliceosome. It is composed of four splicing active native spliceosomes, each resembling an in vitro assembled spliceosome, which are connected by the pr...

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Autors principals: Kinneret Shefer, Joseph Sperling, Ruth Sperling
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science (AAAS) 2014-09-01
Col·lecció:Computational and Structural Biotechnology Journal
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2001037014000348
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