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Complex evolution of the GSTM gene family involves sharing of GSTM1 deletion polymorphism in humans and chimpanzees

Abstract Background The common deletion of the glutathione S-transferase Mu 1 (GSTM1) gene in humans has been shown to be involved in xenobiotic metabolism and associated with bladder cancer. However, the evolution of this deletion has not been investigated. Results In this study, we conducted compa...

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Principais autores: M. Saitou, Y. Satta, O. Gokcumen, T. Ishida
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-04-01
Serier:BMC Genomics
Fag:
Copy number variation
Structural variants
Detoxifying gene family
Primates
Gene conversions
Segmental duplications
Online adgang:http://link.springer.com/article/10.1186/s12864-018-4676-z
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