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The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against <i>Mycobacterium tuberculosis</i>

A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against <i>M. tuberculosis</i>. Two compounds had lower minimum inhibitory concentrations against <i>Mtb...

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Principais autores: Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2024-06-01
Series:Molecules
Assuntos:
nitrofurans
spiroazetidines
tuberculosis
antimycobacterial activity
induced fit docking
deazaflavin-dependent nitroreductase
Acceso en liña:https://www.mdpi.com/1420-3049/29/13/3071
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