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5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens

A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(...

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Kaydedildi:
Asıl Yazarlar: Elizaveta Rogacheva, Lyudmila Kraeva, Alexey Lukin, Lyubov Vinogradova, Kristina Komarova, Mikhail Chudinov, Maxim Gureev, Evgeny Chupakhin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2023-09-01
Seri Bilgileri:Molecules
Konular:
tetrahydropyrazolopyridine
5-nitrofuran derivatives
ESKAPE pathogens
antibacterial testing
nitroreductase
flexible docking
Online Erişim:https://www.mdpi.com/1420-3049/28/18/6491
Etiketler: Etiketle
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