An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein–protein interaction...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Alessia Caputo, Sara Sartini, Elisabetta Levati, Ilaria Minato, Gian Marco Elisi, Adriana Di Stasi, Catherine Guillou, Peter G. Goekjian, Pierre Garcia, David Gueyrard, Stéphane Bach, Arnaud Comte, Simone Ottonello, Silvia Rivara, Barbara Montanini
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-10-01
Schriftenreihe:	Antibiotics
Schlagworte:	yeast Bioluminescence Resonance Energy Transfer (yBRET) protein–protein interaction (PPI) protein–protein interaction inhibitor bacterial RNA polymerase (RNAP) RNAP holoenzyme assembly bacterial transcription inhibitors
Online-Zugang:	https://www.mdpi.com/2079-6382/11/10/1449
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