Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies

Abstract Background DNA methylation (DNAm)-based predictors hold great promise to serve as clinical tools for health interventions and disease management. While these algorithms often have high prediction accuracy, the consistency of their performance remains to be determined. We therefore conduct a...

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Үндсэн зохиолчид:	Anil P. S. Ori, Ake T. Lu, Steve Horvath, Roel A. Ophoff
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2022-10-01
Цуврал:	Genome Biology
Нөхцлүүд:	DNA methylation Infinium MethylationEPIC array DNAm predictors Consistency Replicability Biomarkers
Онлайн хандалт:	https://doi.org/10.1186/s13059-022-02793-w
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!