ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5–10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by genetic screens in model organisms; however, the in...

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Principais autores:	Thomas D Baird, Ken Chih-Chien Cheng, Yu-Chi Chen, Eugen Buehler, Scott E Martin, James Inglese, J Robert Hogg
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2018-03-01
叢編:	eLife
主題:	nonsense-mediated mRNA decay siRNA screen exon junction complex RNA quality control ICE1 UPF3B
在線閱讀:	https://elifesciences.org/articles/33178
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