Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors

Tumor necrosis factor-α (TNF-α) plays a pivotal role in inflammatory response. Dysregulation of TNF can lead to a variety of disastrous pathological effects, including auto-inflammatory diseases. Antibodies that directly targeting TNF-α have been proven effective in suppressing symptoms of these dis...

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Principais autores:	Xiaobing Deng, Xiaoling Zhang, Bo Tang, Hongbo Liu, Qi Shen, Ying Liu, Luhua Lai
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2018-04-01
סדרה:	Frontiers in Chemistry
נושאים:	TNF-α inhibitor dihydrobenzo[cd]indole-6-sulfonamide virtual screening synthesis structure activity analysis
גישה מקוונת:	http://journal.frontiersin.org/article/10.3389/fchem.2018.00098/full
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