Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I, II, IV, and IX) with N1-substituted secondary...

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Bibliografski detalji

Glavni autori:	Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis Group 2018-01-01
Serija:	Journal of Enzyme Inhibition and Medicinal Chemistry
Teme:	Carbonic anhydrase sulfonamides inhibitor indole zinc binding-group
Online pristup:	http://dx.doi.org/10.1080/14756366.2018.1446432
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