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Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization

Background Observational epidemiological studies have reported an association between childhood adiposity and altered cardiac morphology and function in later life. However, whether this is due to a direct consequence of being overweight during childhood has been difficult to establish, particularly...

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Uloženo v:
Hlavní autoři: Genevieve M. Leyden, Helena Urquijo, Alun D. Hughes, George Davey Smith, Tom G. Richardson
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2024-03-01
Edice:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Témata:
cardiac physiology
childhood adiposity
lifecourse epidemiology
Mendelian randomization
vascular structure
On-line přístup:https://www.ahajournals.org/doi/10.1161/JAHA.123.030453
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