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Potential dual inhibitors of Hexokinases and mitochondrial complex I discovered through machine learning approach

Hexokinases (Hks) and mitochondrial complex I (MCI) are involved in the energy metabolism of cells; glycolysis/fermentation and oxidative phosphorylation. Both Hks and MCI are known to play critical roles in either division of metabolic plasticity which enables tumor progression and proliferation in...

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Main Authors: Akachukwu Ibezim, Emmanuel Onah, Sochi Chinaemerem Osigwe, Peter Ukwu Okoroafor, Onyeoziri Pius Ukoha, Jair Lage de Siqueira-Neto, Fidele Ntie-Kang, Karuppasamy Ramanathan
Format: Artigo
Language:Inglês
Published: Elsevier 2024-06-01
Series:Scientific African
Subjects:
Hexokinases
Mitochondrial complex I
Cancer
MACCS fingerprints
Boruta algorithms
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227624001728
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