Heat shock-induced PI(4)P increase drives HSPA1A translocation to the plasma membrane in cancer and stressed cells through PI4KIII alpha activation

Heat shock protein A1A (HSPA1A), a major heat shock (HS) protein, is known to translocate to the plasma membrane (PM) in response to cellular stress and cancer, where it plays protective roles in membrane integrity and stress resistance. Although phosphatidylinositol 4-phosphate [PI(4)P] is essentia...

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Detalhes bibliográficos

Principais autores:	Alberto Arce, Rachel Altman, Allen Badolian, Jensen Low, Azalea Blythe Cuaresma, Georgia Halkia, Uri Keshet, Oliver Fiehn, Robert V. Stahelin, Nikolas Nikolaidis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-02-01
Colecção:	Cell Stress & Chaperones
Assuntos:	HSPA1A localization Lipidomics Phosphatidylinositol 4-phosphate Plasma membrane Stress response
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1355814525000756
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