A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Abstract Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional re...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Springer Nature 2020-03-01
Sarja:	EMBO Molecular Medicine
Aiheet:	activin CAF carcinogenesis mDia2 tumor microenvironment
Linkit:	https://doi.org/10.15252/emmm.201911466
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