A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Abstract Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional re...

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主要な著者:	Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer Nature 2020-03-01
シリーズ:	EMBO Molecular Medicine
主題:	activin CAF carcinogenesis mDia2 tumor microenvironment
オンライン･アクセス:	https://doi.org/10.15252/emmm.201911466
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