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From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach

Abstract Many RNA-binding proteins (RBP) have been associated to several neurodegenerative diseases for which RBP-rich cytoplasmic inclusions represent a major histological hallmark. However, among RBPs, the occurrence with which TDP-43, a nuclear mRNA-binding protein, is detected in cytoplasmic inc...

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Váldodahkkit: Yitian Feng, Vandana Joshi, Serhii Pankivskyi, Marie-Jeanne Clément, Juan Carlos Rengifo-Gonzalez, Aurélien Thureau, David Pastré, Ahmed Bouhss
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2026-01-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-026-68346-y
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