Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

ABSTRACT Cytoplasmic mislocalization and aggregation of transactive response DNA‐binding protein‐43 (TDP‐43) is a common pathological feature of amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology (AD‐TDP); the exact role of protein d...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2026-07-01
Rangatū:	Advanced Science
Ngā marau:	amyotrophic lateral sclerosis mitochondrial impairment protein aggregation protein disulfide isomerase protein phase separation TDP‐43
Urunga tuihono:	https://doi.org/10.1002/advs.202516846
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!