Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice
Abstract Ten eleven translocation (TET) proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is one of the most frequently mutated genes in hematological m...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2024-12-01
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| Colecção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-024-07312-0 |
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