Role of ω-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma

Cyclooxygenase-2 (COX-2) is important in the progression of epithelial tumors. Evidence indicates that ω-6 PUFAs such as arachidonic acid (AA) promote the growth of tumor cells; however, ω-3 fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] inhibit tumor cell proliferation. We...

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Hlavní autoři:	Yvonne Denkins, Doty Kempf, Melissa Ferniz, Shilpa Nileshwar, Dario Marchetti
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2005-06-01
Edice:	Journal of Lipid Research
Témata:	arachidonic acid brain melanoma cancer docosahexaenoic acid eicosapentaenoic acid polyunsaturated fatty acids
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0022227520330327
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