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Successful In Vitro Modification of the <i>Dmd</i> Gene Using Prime Editing

Duchenne muscular dystrophy (DMD) is a fatal X-linked neuromuscular disorder caused by mutations in the dystrophin gene. Prime editing is a versatile genome editing technology capable of introducing precise nucleotide changes without generating double-strand DNA breaks, making it a promising approac...

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Principais autores: Ayesha Siddika, Fatima El Husseiny, Joël Rousseau, Jacques P. Tremblay
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Cells
Fag:
prime editing
Duchenne muscular dystrophy
<i>Dmd</i> gene
myogenic cells
CRISPR/Cas9
RTT–PBS optimization
Online adgang:https://www.mdpi.com/2073-4409/15/9/740
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