Pulmonary exacerbations in early cystic fibrosis lung disease are marked by strong modulation of CD3 and PD-1 on luminal T cells

BackgroundIn chronic cystic fibrosis (CF) lung disease, neutrophilic inflammation and T-cell inhibition occur concomitantly, partly due to neutrophil-mediated release of the T-cell inhibitory enzyme Arg1. However, the onset of this tonic inhibition of T cells, and the impact of pulmonary exacerbatio...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Vincent D. Giacalone, Diego Moncada Giraldo, George L. Silva, Justin Hosten, Limin Peng, Lokesh Guglani, Rabindra Tirouvanziam
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2023-09-01
श्रृंखला:	Frontiers in Immunology
विषय:	cystic fibrosis cytokines exacerbation inflammation neutrophils T cells
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194253/full
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