Changes in cystic fibrosis transmembrane conductance regulator protein expression prior to and during elexacaftor-tezacaftor-ivacaftor therapy

Background: Defects in expression, maturation or function of the epithelial membrane glycoprotein CFTR are causative for the progressive disease cystic fibrosis. Recently, molecular therapeutics that improve CFTR maturation and functional defects have been approved. We aimed to verify whether we cou...

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Detalhes bibliográficos

Principais autores:	Frauke Stanke, Sophia T. Pallenberg, Stephanie Tamm, Silke Hedtfeld, Ella M. Eichhorn, Rebecca Minso, Gesine Hansen, Tobias Welte, Annette Sauer-Heilborn, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Anna-Maria Dittrich
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	elexcaftor-tezacaftor-ivacaftor TRIKAFTA CFTR protein expression CFTR glycosylation CFTR small molecule therapeutics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1114584/full
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