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ScHiCAtt: Enhancing single-cell Hi-C data resolution using attention-based models

The spatial organization of chromatin is fundamental to gene regulation and essential for proper cellular function. The Hi-C technique remains one of the leading methods for unraveling 3D genome structures; however, limited resolution, data sparsity, and incomplete coverage in single-cell Hi-C data...

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Hoofdauteurs: Rohit Menon, H.M.A. Mohit Chowdhury, Oluwatosin Oluwadare
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-01-01
Reeks:Computational and Structural Biotechnology Journal
Onderwerpen:
Hi-C data
Self-attention
Resolution enhancement
Single-cell Hi-C
Data sparsity
Online toegang:http://www.sciencedirect.com/science/article/pii/S2001037025000625
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