The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia

Abstract: Relapsed acute myeloid leukemia (relAML) remains a clinical challenge. We have shown that epigenetic heterogeneity may contribute to transcriptional dysregulation and disease progression in AML, but the specific aberrant transcriptional programs have not been identified. We analyzed molecu...

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Principais autores:	Nicholas Dunham, Zhenjia Wang, Yaseswini Neelamraju, Yan Guo, B. Bishal Paudel, Cem Meydan, Jorge A. Gandara, Fady A Abdelmalak, Hao Fan, Joyce Hardwick, Justin H. Layer, Tak Lee, Bernhard Maier, W. Hayes McDonald, Isaani Patnaik, Subhash Prajapati, Franck Rapaport, Caroline Sheridan, Gloria Sheynkman, Paul Zumbo, Michael W. Becker, Lars Bullinger, Martin P. Carroll, Richard J. D'Andrea, Richard Dillon, Ross L. Levine, Christopher E. Mason, Ari M. Melnick, Donna S. Neuberg, Stefan Bekiranov, Chongzhi Zang, Utpal P. Davé, Francine E. Garrett-Bakelman
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-02-01
Serija:	Blood Neoplasia
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2950328025001219
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