Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation

Despite the activation of autophagy may enable residual cancer cells to survive and allow tumor relapse, excessive activation of autophagy may eventually lead to cell death. However, the details of the association of autophagy with primary resistance in hepatocellular carcinoma (HCC) remain less cle...

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Hlavní autoři:	Hong-Yue Lai, Hsin-Hwa Tsai, Chia-Jui Yen, Liang-Yi Hung, Ching-Chieh Yang, Chung-Han Ho, Hsin-Yin Liang, Feng-Wei Chen, Chien-Feng Li, Ju-Ming Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-01-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	sorafenib metformin autophagy AMPK CEBPD
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2020.596655/full
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