TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways. However, the functions of TGR5 in regulating ma...

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Hlavní autoři:	Yong Shi, Wantong Su, Lei Zhang, Chengyu Shi, Jinren Zhou, Peng Wang, Hao Wang, Xiaoli Shi, Song Wei, Qi Wang, Johan Auwerx, Kristina Schoonjans, Yue Yu, Rui Pan, Haoming Zhou, Ling Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-02-01
Edice:	Frontiers in Immunology
Témata:	nonalcoholic steatohepatitis G protein-coupled bile acid receptor 1 macrophages inflammation NLRP3 inflammasome
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.609060/full
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