Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

Liver-resident macrophages (Kupffer cells, KCs) and autophagy play critical roles in the pathogenesis of toxin-induced liver injury. Recent evidence indicates that autophagy can regulate macrophage M1/M2 polarization under different inflammatory conditions. Polyamines, including putrescine, spermidi...

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Bibliografiska uppgifter

Huvudupphov:	Shun Zhou, Jian Gu, Rui Liu, Song Wei, Qi Wang, Hongbing Shen, Yifan Dai, Haoming Zhou, Feng Zhang, Ling Lu
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2018-05-01
Serie:	Frontiers in Immunology
Ämnen:	liver injury thioacetamide spermine Kupffer cell polarization autophagy
Länkar:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00948/full
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