Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization

AimTo investigate the effect and mechanism of Sitagliptin phosphate on inflammation and macrophage polarization in a mouse model of type 2 diabetes.MethodsIn vitro, Raw264.7 cells were cultured with a high concentration of glucose (HG) and sitagliptin phosphate (SIG). The levels of inflammatory fact...

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Hlavní autoři:	Xiaoxia Hu, Yalong Li, Xinyue Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-04-01
Edice:	Frontiers in Endocrinology
Témata:	diabetes Sitagliptin phosphate inflammation macrophages PPAR-γ
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1544684/full
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