Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts

<b>Background</b>: Fibroblast-like synoviocytes (FLSs) are essential mediators in the expansive growth and invasiveness of rheumatoid synovitis, and patients with a fibroblastic-rich pauci-immune pathotype respond poorly to currently approved antirheumatic drugs. Galectin-9 (Gal-9) has been reported...

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Hlavní autoři:	Morten A. Nielsen, Ditte Køster, Akul Y. Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W. Kragstrup, Richard D. Cummings, Bent Deleuran
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-01-01
Edice:	Cells
Témata:	fibroblast Galectin-9 inflammation rheumatoid arthritis
On-line přístup:	https://www.mdpi.com/2073-4409/12/2/327
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