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Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis

Objective: Active rheumatoid arthritis (RA) is accompanied by increased appendicular and axial bone loss, closely associated to the degree of inflammation. The programmed death-1 (PD-1) pathway is important for maintaining peripheral tolerance, and its ligand PD-L2 has recently been associated with...

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Principais autores: Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Aida Solhøj Hansen, Akilan Krishnamurthy, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Midtbøll Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Lakshmanan Annamalai, Malene Hvid, Søren K. Moestrup, Ellen-Margrethe Hauge, Anca Irinel Catrina, Bent Deleuran
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-01-01
Series:Journal of Translational Autoimmunity
Assuntos:
Co-inhibitory receptors
PD-L2
Osteoclasts
Rheumatoid arthritis
Ostoeimmunology
Autoimmunity
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2589909019300280
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