Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

Background: Partial/complete pathologic response following neoadjuvant chemotherapy (NAC) in pancreatic cancer (PDAC) patients undergoing pancreatectomy is associated with improved survival. We sought to determine whether neutrophil-to-lymphocyte ratio (NLR) dynamics predict pathologic response foll...

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Podrobná bibliografie

Hlavní autoři:	Iago de Castro Silva, Anna Bianchi, Nilesh U Deshpande, Prateek Sharma, Siddharth Mehra, Vanessa Tonin Garrido, Shannon Jacqueline Saigh, Jonathan England, Peter Joel Hosein, Deukwoo Kwon, Nipun B Merchant, Jashodeep Datta
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2022-09-01
Edice:	eLife
Témata:	pancreas cancer surgery myeloid-derived suppressor cells (MDSCs) chemotherapy resistance cancer associated fibroblasts neutrophils
On-line přístup:	https://elifesciences.org/articles/78921
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