Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells

Background and Aims: Animal data show that the presence of an oncogenic Kras mutation in pancreatic acinar cells leads to acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasia (PanIN), and pancreatic ductal adenocarcinoma (PDAC). Inflammatory macrophages play an important role in t...

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Autors principals:	Soichiro Ako, Yaroslav Teper, Linda Ye, James Sinnett-Smith, Oscar J. Hines, Enrique Rozengurt, Guido Eibl
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-01-01
Col·lecció:	Gastro Hep Advances
Matèries:	Pancreatic Cancer Statins Macrophages Acinar-to-Ductal Metaplasia
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2772572322000656
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