Effects of bisphosphonates after denosumab discontinuation and treatment effect heterogeneity using causal machine learning

Abstract Discontinuation of denosumab is associated with a rebound increase in osteoporotic fracture (OF) risk, and bisphosphonates (BPs) are commonly recommended as sequential therapy to mitigate this risk. However, their real-world effectiveness—and whether certain patients benefit more than other...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Miryoung Kim, Nakyung Jeon, Hae Sun Suh
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2025-12-01
Σειρά:	Scientific Reports
Θέματα:	Causal effect Treatment effect heterogeneity Bisphosphonates Osteoporotic fractures Machine learning
Διαθέσιμο Online:	https://doi.org/10.1038/s41598-025-28172-6
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